I haven’t actually tried this, but the thought has occurred to me that a great way to reduce comment spam would be to use the following in your .htaccess file:
<IfModule mod_rewrite.c>
RewriteEngine On
RewriteCond %{REQUEST_METHOD} POST
RewriteCond %{REQUEST_URI} .wp-comments-post\.php*
RewriteCond %{HTTP_REFERER} !.*blogdomainname.* [OR]
RewriteCond %{HTTP_USER_AGENT} ^$
RewriteRule (.*) ^http://%{REMOTE_ADDR}/$ [R=301,L]
</IfModule>
Obviously you’ll need to change blogdomainname to your own domain